Publications

Selected Publications

Liu, Q.*, Tabuchi, M.*, Liu, S., Kodama, L., Horiuchi, W., Daniels, J., Chiu, L., Baldoni, D., and Wu, M.N. (2017). Branch-Specific Plasticity of a Bifunctional Dopamine Circuit Encodes Protein Hunger.  Science 356, 534-539.
Bedont, J.L., LeGates, T.A., Buhr, E., Bathini, A., Ling, J.P., Bell, B., Wu, M.N., Wong, P.C., van Gelder, R.N., Mongrain, V., Hattar, S., and Blackshaw, S. (2017).  An LHX1-Regulated Transcriptional Network Controls Sleep/Wake Coupling and Thermal Resistance of the Central Circadian Clockworks.  Curr Biol 27, 128-136.
Liu, S.*, Liu, Q.*, Tabuchi, M., and Wu, M.N. (2016). Sleep Drive is Encoded by Neural Plastic Changes in a Dedicated Circuit. Cell 165, 1347-1360.  (Previewed in Cell) (Recommended by Faculty of 1000).  
Spira, A.P., Gonzalez, C.E., Venkatraman, V.K., Wu, M.N., Pacheco, J., Simonsick, E.M., Ferrucci, L., and Resnick, S.M. (2016). Sleep Duration and Subsequent Cortical Thinning in Cognitively Normal Older Adults. Sleep 39, 1121-1128
Tabuchi, M., Lone, S.R., Liu, S., Liu, Q., Zhang, J., Spira, A.P., and Wu, M.N. (2015). Sleep Interacts with Abeta to Modulate Intrinsic Neuronal Excitability. Curr Biol 25, 1-11.  (Previewed in Curr Biol)
Riabinina, O., Luginbuhl, D., Marr, E., Liu, S., Wu, M.N., Luo, L., and Potter, C.J. (2015). Improved and Expanded Q-system Reagents for Genetic Manipulations. Nat Methods 12, 219-222.
Spira, A.P., Yager, C., Brandt, J., Smith G.S., Zhou, Y., Mathur, A., Kumar, A., Brasic, J.R., Wong, D.F., and Wu, M.N. (2014). Objectively-Measured Sleep and Beta-Amyloid Burden in Older Adults: A Pilot Study. Sage Open Medicine 2: DOI: 205031214546520.
Liu, S.*, Lamaze, A.*, Liu, Q., Tabuchi, M., Yang, Y., Fowler, M., Bharadwaj, R., Zhang, J., Bedont, J., Blackshaw, S., Lloyd, T.E., Montell, C., Sehgal, A., Koh, K.*, and Wu, M.N.(2014).  WIDE AWAKE Mediates the Circadian Timing of Sleep Onset.  Neuron 82, 151-166.
Spira, A.P., Gamaldo, A.A., An, Y., Wu, M.N., Simonsick, E.M., Bilgel, M., Zhou, Y., Wong, D.F., Ferrucci, L., and Resnick, S.M. (2013). Self-Reported Sleep and Beta-Amyloid Deposition in Community-Dwelling Older Adults. JAMA Neurology 70, 1537-1543.  
Liu, Q., Liu, S., Kodama, L., Driscoll, M.R., and Wu, M.N. (2012). Two Dopaminergic Neurons Signal to the Dorsal Fan-shaped Body to Promote Wakefulness in Drosophila. Curr Biol 22, 2114-2123.  (Previewed in Curr Biol)
Wu, M.N. and Raizen, D.R. (2011). Notch signaling: a role in sleep and stress. Curr Biol. 21, R397-R398.
Raizen, D.R. and Wu, M.N. (2011). Genome-wide analysis of sleep disorders. Chest 139, 446-452.

Wu, M.N.* (co-first author), Joiner, W.J.*, Dean, T.*, Smith, C., Yue, Z., Hoshi, T., Sehgal, A.S., and Koh, K. (2010). Sleepless regulates Shaker expression, localization, and function. Nature Neurosci 13, 69-75. (Highlighted by Faculty of 1000).

Zheng, X., Koh, K., Sowcik, M., Smith, C., Chen, D., Wu, M.N., and Sehgal, A.S. (2009). An isoform-specific mutant reveals a role of PDP1e in the circadian oscillator. J. Neurosci 29, 10920-10927.

Wu, M.N.* (co-first author), Ho, K.*, Yue, Z., Koh, K., and Sehgal, A.S. (2009). The effects of caffeine on sleep and circadian rhythms in Drosophila require PKA signalling, but not the adenosine receptor. J. Neurosci 29, 11029-11037.

Koh, K.*, Joiner, W.J.*, Wu, M.N.* (co-first author), Yue, Z., Smith, C., and Sehgal, A.S. (2008). Identification of Sleepless, a sleep promoting factor. Science 321, 372-376.  (Previewed in Science Signaling)

Wu, M.N., Koh, K., Yue, Z., Joiner, W.J., and Sehgal, A.S. (2008). A genetic screen for sleep and circadian mutants reveals mechanisms underlying sleep in Drosophila. Sleep 31, 465-472.

Sehgal, A., Joiner, W.J., Crocker, A., Koh, K., Sathyanarayanan, S., Fang, Y., Wu, M.N., Williams, J.A., and Zheng, X. (2007). Molecular analysis of sleep:wake cycles in Drosophila. Cold Spring Harb Symp Quant Biol 72, 557-564.

Lloyd, T.E., Atkinson, R., Wu, M.N., Zhou, Y., Pennetta, G., and Bellen, H.J. (2002). HRS regulates endosome membrane invagination and tyrosine kinase receptor signalling in Drosophila. Cell 108, 261-269.

Fergestad, T.*, Wu, M.N.* (co-first author), Schulze, K.L., Lloyd, T.E., Bellen, H.J., and Broadie, K. (2001). Targeted mutations in the syntaxin H3 domain specifically disrupt SNARE complex function in synaptic transmission. J. Neurosci 21, 9142-9150.

Mao, Y., Nickitenko, A., Duan, X., Lloyd, T.E., Wu, M.N., Bellen H.J., and Quiocho, F.A. (1999). Crystal structure of the VHS and FYVE tandem domains of HRS, a protein involved in membrane trafficking and signal transduction. Cell 100, 447-456.

Wu, M.N., Fergestad, T., Lloyd, T.E., He, Y., Broadie, K., and Bellen, H.J. (1999). Syntaxin 1A interacts with multiple exocytic proteins to regulate neurotransmitter release in vivo. Neuron 23, 593-605.

Wu, M.N., Littleton, J.T., Bhat, M.A., Prokop, A., and Bellen, H.J. (1998). ROP, the Drosophila Sec1 homolog, interacts with syntaxin and regulates neurotransmitter release in a dosage dependent manner. EMBO J. 17, 127-139.

Wu, M.N. and Bellen, H.J. (1997). Genetic dissection of synaptic transmission in Drosophila. Curr Opin Neurobio 7, 624-630.

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