Publications
Brown, M.P., Verma, S., Palmer, I., Zuniga, A.G., Mehta, A., Rosensweig, C., Keles, M.F., and Wu, M.N. (2024). A subclass of evening cells promotes the switch from arousal to sleep at dusk. Curr Biol (in press).
Han, E.*, Lee, S.-S.*, Park, K.H., Blum, I.D., Liu, Q., Mehta, A., Palmer, I., Issa, H., Han, A., Brown, M.P., Sanchez-Franco, V.M., Velasco, M., Tabuchi, M., and Wu, M.N. (2024). Tob Regulates the Timing of Sleep Onset at Night in Drosophila. J. Neurosci (in press).
Liu, Q.*, Bell, B.J.*, Kim, D.-W., Lee, S.-S., Keles, M.F., Liu, Q., Blum, I.D., Wang, A.A., Blank, E.J., Xiong, J., Bedont, J.L., Chang, A.J., Issa, H., Cohen, J.Y., Blackshaw, S., and Wu, M.N. (2023). A Clock-Dependent Brake for Rhythmic Arousal in the Dorsomedial Hypothalamus. Nat Commun 14, 6381.
Ho, M.C.W.*, Tabuchi, M.*, Xie, X., Brown, M., Luu, S., Wang, S., Kolodkin, A., Liu, S., and Wu, M.N. (2022). Sleep Need-Dependent Changes in Functional Connectivity Facilitate Transmission of Homeostatic Sleep Drive. Curr Biol 32, 4957-4966.
Blum, I.D.*, Keles, M.F.*, Baz, E.-S., Han, E., Park, K., Luu, S., Issa, H., Brown, M., Ho, M.C.W., Tabuchi, M., Liu, S.*, and Wu, M.N.* (2021). Astroglial Calcium Signaling Encodes Sleep Need in Drosophila. Curr Biol 31, 150-162.
Bell, B.J.*, Wang, A.A.*, Kim, D.W., Xiong, J., Blackshaw, S., and Wu, M.N. (2020). Characterization of mWAKE Expression in the Murine Brain. J Comp Neurol, doi.org/10.1002/cne.25066.
Lee, S.S. and Wu, M.N. (2020). Neural Circuit Mechanisms Encoding Motivational States in Drosophila. Curr Opin Neurobiol 64, 135-142.
Blum, I.D. and Wu, M.N. (2019). Sleep: Slow Waves Quiet the Fly's Mind. Curr Biol 29, R1129-R1131.
Xie, X., Tabuchi, M., Corver, A., Duan, G., Wu, M.N., and Kolodkin, A. (2019). Semaphorin-2B Regulates Sleep Circuit Formation in the Drosophila Central Brain. Neuron 104, 322-337.
Liang, X., Ho, M.C.W., Zhang, Y., Li, Y., Wu, M.N., Holy, T.E., and Taghert, P. (2019). Morning and Evening Circadian Pacemakers Independently Drive Premotor Centers via a Specific Dopamine Relay. Neuron 102, 843-857.
Tabuchi, M., Monaco, J.D., Duan, G., Bell, B., Liu, S., Liu, Q., Zhang, K., and Wu, M.N. (2018). Clock-Generated Temporal Codes Determine Synaptic Plasticity to Control Sleep. Cell 175, 1-15. (Previewed in Cell)
Xie, T.*, Ho, M.C.W.*, Liu, Q., Horiuchi, W., Lin, C.-C., Task, D., Luan, H., White, B.W., Potter, C.J., and Wu, M.N. (2018). A Genetic Toolkit for Dissecting Dopamine Circuit Function in Drosophila. Cell Rep 23, 652-665.
Blum, I.D., Bell, B., and Wu, M.N. (2018). Time for Bed: Genetic Mechanisms Mediating the Circadian Regulation of Sleep. Trends Genet 34, 379-388.
Tabuchi, M. and Wu, M.N. (2018). Sleep: Setting the 'Circadian' Alarm Clock. Curr Biol 28, R26-R28.
Xie, X., Tabuchi, M., Brown, M.P., Mitchell, S.P., Wu, M.N., and Kolodkin, A.L. (2017). The Laminar Organization of the Drosophila Ellipsoid Body is Semaphorin-dependent and Prevents the Formation of Ectopic Synaptic Connections. eLife 6:e25328. doi: 10.7554/eLife.25328.
Liu, Q.*, Tabuchi, M.*, Liu, S., Kodama, L., Horiuchi, W., Daniels, J., Chiu, L., Baldoni, D., and Wu, M.N. (2017). Branch-Specific Plasticity of a Bifunctional Dopamine Circuit Encodes Protein Hunger. Science 356, 534-539.
Bedont, J.L., LeGates, T.A., Buhr, E., Bathini, A., Ling, J.P., Bell, B., Wu, M.N., Wong, P.C., van Gelder, R.N., Mongrain, V., Hattar, S., and Blackshaw, S. (2017). An LHX1-Regulated Transcriptional Network Controls Sleep/Wake Coupling and Thermal Resistance of the Central Circadian Clockworks. Curr Biol 27, 128-136.
Liu, S.*, Liu, Q.*, Tabuchi, M., and Wu, M.N. (2016). Sleep Drive is Encoded by Neural Plastic Changes in a Dedicated Circuit. Cell 165, 1347-1360. (Previewed in Cell) (Recommended by Faculty of 1000).
Spira, A.P., Gonzalez, C.E., Venkatraman, V.K., Wu, M.N., Pacheco, J., Simonsick, E.M., Ferrucci, L., and Resnick, S.M. (2016). Sleep Duration and Subsequent Cortical Thinning in Cognitively Normal Older Adults. Sleep 39, 1121-1128.
Tabuchi, M., Lone, S.R., Liu, S., Liu, Q., Zhang, J., Spira, A.P., and Wu, M.N. (2015). Sleep Interacts with Abeta to Modulate Intrinsic Neuronal Excitability. Curr Biol 25, 1-11. (Previewed in Curr Biol)
Riabinina, O., Luginbuhl, D., Marr, E., Liu, S., Wu, M.N., Luo, L., and Potter, C.J. (2015). Improved and Expanded Q-system Reagents for Genetic Manipulations. Nat Methods 12, 219-222.
Spira, A.P., Yager, C., Brandt, J., Smith G.S., Zhou, Y., Mathur, A., Kumar, A., Brasic, J.R., Wong, D.F., and Wu, M.N. (2014). Objectively-Measured Sleep and Beta-Amyloid Burden in Older Adults: A Pilot Study. Sage Open Medicine 2: DOI: 205031214546520.
Liu, S.*, Lamaze, A.*, Liu, Q., Tabuchi, M., Yang, Y., Fowler, M., Bharadwaj, R., Zhang, J., Bedont, J., Blackshaw, S., Lloyd, T.E., Montell, C., Sehgal, A., Koh, K.*, and Wu, M.N.* (2014). WIDE AWAKE Mediates the Circadian Timing of Sleep Onset. Neuron 82, 151-166.
Spira, A.P., Gamaldo, A.A., An, Y., Wu, M.N., Simonsick, E.M., Bilgel, M., Zhou, Y., Wong, D.F., Ferrucci, L., and Resnick, S.M. (2013). Self-Reported Sleep and Beta-Amyloid Deposition in Community-Dwelling Older Adults. JAMA Neurology 70, 1537-1543.
Liu, Q., Liu, S., Kodama, L., Driscoll, M.R., and Wu, M.N. (2012). Two Dopaminergic Neurons Signal to the Dorsal Fan-shaped Body to Promote Wakefulness in Drosophila. Curr Biol 22, 2114-2123. (Previewed in Curr Biol)
Wu, M.N. and Raizen, D.R. (2011). Notch signaling: a role in sleep and stress. Curr Biol. 21, R397-R398.
Raizen, D.R. and Wu, M.N. (2011). Genome-wide analysis of sleep disorders. Chest 139, 446-452.
Wu, M.N.* (co-first author), Joiner, W.J.*, Dean, T.*, Smith, C., Yue, Z., Hoshi, T., Sehgal, A.S., and Koh, K. (2010). Sleepless regulates Shaker expression, localization, and function. Nature Neurosci 13, 69-75. (Highlighted by Faculty of 1000).
Zheng, X., Koh, K., Sowcik, M., Smith, C., Chen, D., Wu, M.N., and Sehgal, A.S. (2009). An isoform-specific mutant reveals a role of PDP1e in the circadian oscillator. J. Neurosci 29, 10920-10927.
Wu, M.N.* (co-first author), Ho, K.*, Yue, Z., Koh, K., and Sehgal, A.S. (2009). The effects of caffeine on sleep and circadian rhythms in Drosophila require PKA signalling, but not the adenosine receptor. J. Neurosci 29, 11029-11037.
Koh, K.*, Joiner, W.J.*, Wu, M.N.* (co-first author), Yue, Z., Smith, C., and Sehgal, A.S. (2008). Identification of Sleepless, a sleep promoting factor. Science 321, 372-376. (Previewed in Science Signaling)
Wu, M.N., Koh, K., Yue, Z., Joiner, W.J., and Sehgal, A.S. (2008). A genetic screen for sleep and circadian mutants reveals mechanisms underlying sleep in Drosophila. Sleep 31, 465-472.